ePrints@IIScePrints@IISc Home | About | Browse | Latest Additions | Advanced Search | Contact | Help

Zintrons in rat \alpha-lactalbumin gene

Meera, G and Ramesh, N and Brahmachari, Samir K (1989) Zintrons in rat \alpha-lactalbumin gene. In: FEBS Letters, 251 (1-2). pp. 245-249.

[img] PDF
Restricted to Registered users only

Download (457kB) | Request a copy


The eukaryotic genome is characterised by the occurrence of a large amount of repetitive DNA which exists within and around coding sequences. Random repeats of $(TG)_n$ sequences have been observed in several introns. In this paper we show that $(TG)_{14}$and $(TG)_{24}$ sequences present in the third intron of rat \alpha-lactalbumin gene adopt left-handed Z-helices under varying superhelical densities. The overall sequence of the parent plasmid further influenced the level of supercoiling at which the B to Z transition could be induced in $(TG)_n$ sequences. Such Z-potential intervening sequences. (zintrons) could act as buffers to maintain desired levels of supercoiling near the transcribed sequences.

Item Type: Journal Article
Publication: FEBS Letters
Publisher: Elsevier Science B.V.
Additional Information: Copyright of this article belongs to Federation of European Biochemical Societies.
Keywords: Lactalbumin, α-;Intron sequence;DNA, Z-;DNA supercoiling;(Rat)
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 13 Feb 2008
Last Modified: 19 Sep 2010 04:42
URI: http://eprints.iisc.ac.in/id/eprint/12919

Actions (login required)

View Item View Item