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Synthesis and antitubercular activity of N-(2-naphthyl)glycine hydrazide analogs

Ramamurthy, B and Bhatt, MV (1989) Synthesis and antitubercular activity of N-(2-naphthyl)glycine hydrazide analogs. In: Journal of Medicinal Chemistry, 32 (11). pp. 2421-2426.

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N-(2-Naphthyl)glycine hydrazide analogues were synthesized and tested for possible in vitro antitubercular activity. N-( 2-Naphthy1)alanine hydrazide (3), N-methyl-N-(2-naphthy1)glycine hydrazide (51, N-(6-methoxy-2-naphthyl)glycine hydrazide (7), and 3-(2-naphthylamino)butyric acid hydrazide (23) showed potent inhibitory action against Mycobacterium tuberculosis $H_{37}R_v$ in Youman's medium at concentrations ranging from 0.5 to 10.0 $\mu$g/mL. These compounds showed significant inhibitory action against isonicotinic acid hydrazide and streptomycin-resistant strains of M. tuberculosis. N-(6-Quinolyl)glycine hydrazide (18) and 3-(2-quinolylamino)butpic acid hydrazide (24), which are bioisosteres of compounds 1 and 23, showed loss of antitubercular activity at low concentrations.

Item Type: Journal Article
Publication: Journal of Medicinal Chemistry
Publisher: Bentham Science Publishers
Additional Information: Copyright of this article belongs to Bentham Science Publishers
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 23 Feb 2008
Last Modified: 19 Sep 2010 04:42
URI: http://eprints.iisc.ac.in/id/eprint/12869

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