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One-pot synthesis of 2-chloronicotinonitriles and fused 2-chloro-3-cyanopyridines

Sreenivasulu, M and Rao, Krishna GS (1989) One-pot synthesis of 2-chloronicotinonitriles and fused 2-chloro-3-cyanopyridines. In: Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 28B (7). pp. 584-586.

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Abstract

Vilsmeier reaction (POCl3, Me2NHCHO) of alkylidenemalononitriles gives the title compds. by in situ generation of an aldehyde equiv. followed by cyclization. E.g., PrCH:C(CN)2 gives 19% chloroethylnicotinonitrile I.

Item Type: Journal Article
Publication: Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry
Publisher: National Institute of Science Communication and Information Resources
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 12 Feb 2008
Last Modified: 27 Aug 2008 13:08
URI: http://eprints.iisc.ac.in/id/eprint/12769

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