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Decavanadate acts like an $\alpha$-adrenergic agonist in redistributing protein kinase C activity

Gullapalli, Sharada and Kurup, Ramakrishna CK and Ramasarma, T (1990) Decavanadate acts like an $\alpha$-adrenergic agonist in redistributing protein kinase C activity. In: FEBS Letters, 267 (1). pp. 93-95.

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Perfusion of rat livers with polyvanadate, but not metavanadate, was found to increase in plasma membrane and decrease in cytosol protein kinase C activity, similar to that obtained with phenylephrine, an $\alpha$-adrenergic agonist. The effect was prevented by phenoxybenzamine, but not by propranolol implicating $\alpha$-adrenergic receptor activation. Comparison of crystal structures of decavanadate and nonadrenaline revealed the occurrence of a structural feature of O-O-O(N) with distances of 5.5 $\AA$ and 2.9 $\AA$.

Item Type: Journal Article
Publication: FEBS Letters
Publisher: Elsevier Science B.V.
Additional Information: Copyright of this article belongs to Elsevier Science B.V.
Keywords: Decavanadate;Protein kinase C;α-Adrenergic agonist
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 03 Dec 2007
Last Modified: 19 Sep 2010 04:41
URI: http://eprints.iisc.ac.in/id/eprint/12677

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