Nuclear magnetic resonance and thermal studies of drug doped dipalmitoyl phosphatidyl choline-$H_2O$ systems

Deniz, Usha K and Parvathanathan, PS and Datta, Geeta and Khetrapal, CL and Ramanathan, KV and Suryaprakash, N and Raghotama, S (1990) Nuclear magnetic resonance and thermal studies of drug doped dipalmitoyl phosphatidyl choline-$H_2O$ systems. In: Journal of Biosciences, 15 (3). pp. 117-123.

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Abstract

The influence of the sulfone drugs, diamino diphenyl sulfone and diamino monophenyl sulfone on the phase transitions and dynamics of dipalmitoyl phosphatidyl choline-$H_2O/D_2O$ vesicles have been investigated using differential scanning calorimetry and nuclear magnetic resonance. Our results show that diamino diphenyl sulfone interacts quite strongly with the headgroups of dipalmitoyl phosphatidyl choline whereas the diamino monophenyl sulfone-dipalmitoyl phosphatidyl choline interaction is quite weak. This is attributed to the difference in the structure and hydrophobic character of the two drugs.

Item Type:	Journal Article
Publication:	Journal of Biosciences
Publisher:	Indian Academy of Science
Additional Information:	Copyright of this article belongs to Indian Academy of Science
Keywords:	Dipalmitoyl phosphatidyl choline;drug-membrane interaction;differential scanning calorimetry;1H NMR;31P NMR.
Department/Centre:	Division of Chemical Sciences > Sophisticated Instruments Facility (Continued as NMR Research Centre)
Date Deposited:	19 Dec 2007
Last Modified:	05 Jan 2011 07:18
URI:	http://eprints.iisc.ac.in/id/eprint/12564

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