Shibani, Mitra K and Shaila, MS and Karande, Anjali and Nayak, Rabindranath (2002) Idiotype and anti-idiotype specific T cell responses on transplantation with hybridomas reactive to viral hemagglutinin and human tumor antigen. In: Immunology Letters, 80 (2). pp. 81-87.
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Abstract
B cell hybridomas expressing class I and II MHC molecules and producing antibodies directed against hemagglutinin protein of Rinderpest virus and human Mucin-1 have been used as surrogate B cells to study T cell responses against the antigens. The observed CTL and lymphoproliferative response indicates that anti-idiotypic B cells termed Jerne cells stimulate both T helper and T cytotoxic cells by virtue of their ability to present recycled or regurgitated peptido-mimics of antigen to T helper cells through class II MHC and de novo synthesized peptido-mimics of antigens to CTLs. Thus, T cell memory response can be perpetuated by anti-idiotypic Jerne B cells and these findings lend support to the earlier proposed relay hypothesis for perpetuation of immunological memory (IM).
Item Type: | Journal Article |
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Publication: | Immunology Letters |
Publisher: | Elsevier Science B.V. |
Additional Information: | Copyright of this article belongs to Elsevier Science B.V. |
Keywords: | Idiotype;Immunological memory;T cell responses;Relay hypothesis |
Department/Centre: | Division of Biological Sciences > Biochemistry Division of Biological Sciences > Microbiology & Cell Biology |
Date Deposited: | 03 Oct 2007 |
Last Modified: | 19 Sep 2010 04:40 |
URI: | http://eprints.iisc.ac.in/id/eprint/12040 |
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