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Alterations in tumour suppressor gene p53 in human gliomas from Indian patients

Phatak, Pornima and Selvi, Kalai S and Divya, T and Hegde, AS and Hegde, Sridevi and Somasundaram, Kumaravel (2002) Alterations in tumour suppressor gene p53 in human gliomas from Indian patients. In: Journal of Biosciences, 27 (7). pp. 673-678.


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Alterations in the tumour suppressor p53 gene are among the most common defects seen in a variety of human cancers. In order to study the significance of the p53 gene in the genesis and development of human glioma from Indian patients, we checked 44 untreated primary gliomas for mutations in exons 5-9 of the p53 gene by PCR-SSCP and DNA sequencing. Sequencing analysis revealed six missense mutations. The incidence of p53 mutations was 13.6% (6 of 44). All the six mutations were found to be located in the central core domain of p53, which carries the sequence-specific DNA-binding domain. These results suggest a rather low incidence but a definite involvement of p53 mutations in the gliomas of Indian patients.

Item Type: Journal Article
Publication: Journal of Biosciences
Publisher: Indian Academy of Sciences
Additional Information: Copyright belongs to Indian Academy of Sciences.
Keywords: Gliomas;mutations;p53;single strand conformation polymorphism
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 25 Sep 2007
Last Modified: 19 Sep 2010 04:39
URI: http://eprints.iisc.ac.in/id/eprint/11910

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