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Preexposure Efficacy of a Novel Combination DNA and Inactivated Rabies Virus Vaccine

Biswas, Subhabrata and Reddy, GS and Srinivasan, VA and Rangarajan, PN (2001) Preexposure Efficacy of a Novel Combination DNA and Inactivated Rabies Virus Vaccine. In: Human Gene Therapy, 12 (15). pp. 1917-1922.

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Official URL: http://online.liebertpub.com/doi/abs/10.1089/10430...


Several strategies are being examined to enhance the potency of DNA rabies vaccine (DRV) so that it can be used for both prophylaxis and postexposure therapy of rabies. In this study, we report a novel combination rabies vaccine (CRV) containing a low dose of cell culture-derived inactivated rabies virus vaccine and DRV. Mice immunized with CRV develop higher levels of rabies virus-neutralizing antibodies (RVNA) than those immunized with DRV and are completely protected against peripheral as well as intracerebral rabies virus challenge. The quantity of inactivated rabies virus vaccine required for enhancing the potency of DRV can be 625-fold lower than that of a standard dose of inactivated rabies virus vaccine. CRV induces higher levels of RVNA than DRV in cattle as well. Thus, we demonstrate for the first time that coinoculation of DNA vaccine and a low dose of inactivated virus vaccine can be developed into a novel cost-effective vaccination strategy for combating rabies in particular, and infectious diseases in general.

Item Type: Journal Article
Publication: Human Gene Therapy
Publisher: Mary Ann Liebert Inc.
Additional Information: Copyright of this article belongs to Mary Ann Liebert Inc.
Keywords: Infection;Molecular Genetics;Biochemistry; MolecularBiophysics;Pharmacology
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 26 Sep 2007
Last Modified: 03 Feb 2012 07:19
URI: http://eprints.iisc.ac.in/id/eprint/11902

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