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Establishment of the need for oestrogen during implantation in non-human primates

Rao, AJ and Ramachandra, SG and Ramesh, V and Krishnamurthy, HN and Ravindranath, N and Moudgal, NR (2007) Establishment of the need for oestrogen during implantation in non-human primates. In: Reproductive BioMedicine Online, 14 (5). pp. 563-571.

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Deprivation of oestrogen during post-ovulatory mated cycles in proven fertile female bonnet monkeys by tamoxifen, aromatase inhibitor or oestrogen antiserum resulted in inhibition of pregnancy establishment in all three groups of animals. However, more than 85% of the animals became pregnant within three exposures to proven fertile males in the control group. These results suggest the requirement for oestrogen in pregnancy establishment in primates. Based on this conclusion, it is suggested that use of a suitable and potent anti-oestrogenic compound can be exploited as an alternative approach to contraception.

Item Type: Journal Article
Publication: Reproductive BioMedicine Online
Publisher: Reproductive Healthcare Ltd
Additional Information: Copyright of this article belongs to Reproductive Healthcare Ltd.
Keywords: anti oestrogen;aromatase inhibitors;fertility;non human primates;tamoxifen
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 14 Aug 2007
Last Modified: 02 Feb 2012 10:09
URI: http://eprints.iisc.ac.in/id/eprint/11702

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