Sriram, Dharmarajan and Bal, Tanushree Ratan and Yogeeswari, Perumal and Radha, Deshpande R and Nagaraja, Valakunja (2006) Evaluation of antimycobacterial and DNA gyrase inhibition of fluoroquinolone derivatives. In: Journal of General and Applied Microbiology, 52 (4). pp. 195-200.
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Abstract
The antimycobacterial activity (both in vitro and in vivo) and DNA gyrase inhibition of newly synthesized fluoroquinolone derivatives were tested against Mycobacterium tuberculosis $H_{37}$Rv and Mycobacterium smegmatis, respectively. Among the synthesized compounds, compound F11 was found to exhibit the most potent in vitro antimycobacterial activity with a MIC value of 0.78 μg/ml, and a selectivity index of more than 80 while not being cytotoxic to the Vero cell line up to 62.5 μg/ml. When evaluated for in vivo antimycobacterial activity, compound F11 demonstrated a paramount decrease of bacterial load in lung and spleen tissues compared to the control and better than the standard drug ciprofloxacin.
Item Type: | Journal Article |
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Publication: | Journal of General and Applied Microbiology |
Publisher: | Microbiology Research Foundation |
Additional Information: | Copyright of this article belongs to Microbiology Research Foundation. |
Keywords: | DNA gyrase inhibition;Fluoroquinolone derivatives;Isatin derivatives;Mycobacterium smegmatis;Mycobacterium tuberculosis. |
Department/Centre: | Division of Biological Sciences > Microbiology & Cell Biology |
Date Deposited: | 11 Aug 2008 |
Last Modified: | 19 Sep 2010 04:38 |
URI: | http://eprints.iisc.ac.in/id/eprint/11397 |
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