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A Nuclear Magnetic Resonance Study of The Interaction of Serotonin With Gangliosides

Krishnan, KS and Balaram, P (1976) A Nuclear Magnetic Resonance Study of The Interaction of Serotonin With Gangliosides. In: FEBS Letters, 63 (2). pp. 313-315.

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Serotonin has important central nervous system functions [1 ]. It has been implicated as an excitatory neurotransmitter and its altered levels contribute to psychopathic conditions like schizophrenia [2]. The high specificity of neurotransmitters suggests that their actions are mediated by specific binding to a receptor site on the synaptic plasma membrane. Marchbanks has shown that serotonin binds to nerve ending particles with three major binding affinities [3]. The high affinity binding site (Ka%106 M -1 ) is recovered in n-butanol extracts of brain. Binding is inhibited by d-LSD and destroyed on neuraminidase treatment. Gangliosides have been suggested as the serotonin binding component and consequently as the possible 'receptor' site. Gangliosides are generally located on the outer surface of nerve cells [4]. The ability of purified gangliosides to bind serotonin in aqueous solution has been demonstrated [5,6]. We describe in this communication the results of an 1H n.m.r, study, of the interaction of serotonin with monkey brain gangliosides.

Item Type: Journal Article
Publication: FEBS Letters
Publisher: Elsevier
Additional Information: Copyright for this article belongs to Elsevier Science Ltd
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 23 Jul 2004
Last Modified: 19 Sep 2010 04:14
URI: http://eprints.iisc.ac.in/id/eprint/1138

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