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Functional Cooperation Between Topoisomerase I and Single Strand DNA-binding Protein

Sikder, Devanjan and Unniraman, Shyam and Bhaduri, Tisha and Nagaraja, Valakunja (2001) Functional Cooperation Between Topoisomerase I and Single Strand DNA-binding Protein. In: Journal of Molecular Biology, 306 . pp. 669-679.


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Protein-protein interactions play important role in cell biochemistry by favorably or adversely influencing major molecular events. In most documented cases, the interaction is direct between the partner molecules. Influence of activity in the absence of direct physical interaction between DNA transaction proteins is another important means of modulation. We show here that single strand binding protein stimulates DNA topoisomerase I activity without direct protein-protein interactions. The stimulation is specific to topoisomerase I, as DNA graze activity is unaffected by SSB. We propose that such cases of functional collaboration between DNA transaction proteins play important roles in vivo.

Item Type: Journal Article
Publication: Journal of Molecular Biology
Publisher: Academic Press
Keywords: Gyrase;topoisomerase 1;single strand binding protein; functional cooperation
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 21 Jul 2004
Last Modified: 19 Sep 2010 04:14
URI: http://eprints.iisc.ac.in/id/eprint/1100

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