Norgard, RJ and Pitarresi, JR and Maddipati, R and Aiello-Couzo, NM and Balli, D and Li, J and Yamazoe, T and Wengyn, MD and Millstein, ID and Folkert, IW and Rosario-Berrios, DN and Kim, I-K and Bassett, JB and Payne, R and Berry, CT and Feng, X and Sun, K and Cioffi, M and Chakraborty, P and Jolly, MK and Gutkind, JS and Lyden, D and Freedman, BD and Foskett, JK and Rustgi, AK and Stanger, BZ (2021) Calcium signaling induces a partial EMT. In: EMBO Reports .
Full text not available from this repository.Abstract
Epithelial plasticity, or epithelial-to-mesenchymal transition (EMT), is a well-recognized form of cellular plasticity, which endows tumor cells with invasive properties and alters their sensitivity to various agents, thus representing a major challenge to cancer therapy. It is increasingly accepted that carcinoma cells exist along a continuum of hybrid epithelial�mesenchymal (E-M) states and that cells exhibiting such partial EMT (P-EMT) states have greater metastatic competence than those characterized by either extreme (E or M). We described recently a P-EMT program operating in vivo by which carcinoma cells lose their epithelial state through post-translational programs. Here, we investigate the underlying mechanisms and report that prolonged calcium signaling induces a P-EMT characterized by the internalization of membrane-associated E-cadherin (ECAD) and other epithelial proteins as well as an increase in cellular migration and invasion. Signaling through Gαq-associated G-protein-coupled receptors (GPCRs) recapitulates these effects, which operate through the downstream activation of calmodulin-Camk2b signaling. These results implicate calcium signaling as a trigger for the acquisition of hybrid/partial epithelial�mesenchymal states in carcinoma cells. © 2021 The Authors
| Item Type: | Journal Article |
|---|---|
| Publication: | EMBO Reports |
| Publisher: | John Wiley and Sons Inc |
| Additional Information: | The copyright for this article belongs to John Wiley and Sons Inc |
| Department/Centre: | Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering |
| Date Deposited: | 29 Nov 2021 11:16 |
| Last Modified: | 29 Nov 2021 11:16 |
| URI: | http://eprints.iisc.ac.in/id/eprint/69987 |
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