Genotoxic stress response: What is the role of cytoplasmic mRNA fate?

Mohanan, G and Das, A and Rajyaguru, PI (2021) Genotoxic stress response: What is the role of cytoplasmic mRNA fate? In: BioEssays, 43 (8).

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Abstract

Genotoxic stress leads to DNA damage which can be detrimental to the cell. A well-orchestrated cellular response is mounted to manage and repair the genotoxic stress-induced DNA damage. Our understanding of genotoxic stress response is derived mainly from studies focused on transcription, mRNA splicing, and protein turnover. Surprisingly not as much is understood about the role of mRNA translation and decay in genotoxic stress response. This is despite the fact that regulation of gene expression at the level of mRNA translation and decay plays a critical role in a myriad of cellular processes. This review aims to summarize some of the known findings of the role of mRNA translation and decay by focusing on two categories of examples. We discuss examples of mRNA whose fates are regulated in the cytoplasm and RNA-binding proteins that regulate mRNA fates in response to genotoxic stress. © 2021 Wiley Periodicals LLC

Item Type:	Journal Article
Publication:	BioEssays
Publisher:	John Wiley and Sons Inc
Additional Information:	The copyright for this article belongs to John Wiley and Sons Inc
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	24 Aug 2021 10:30
Last Modified:	24 Aug 2021 10:30
URI:	http://eprints.iisc.ac.in/id/eprint/69382

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