Katoch, A and Tripathi, SK and Pal, A and Das, S (2021) Regulation of miR-186-YY1 axis by the p53 translational isoform ∆40p53: implications in cell proliferation. In: Cell Cycle, 20 (5-6). pp. 561-574.
Full text not available from this repository.Abstract
We have earlier shown that p53-FL and its translational isoform ∆40p53 are differentially regulated. In this study, we have investigated the cellular effect of ∆40p53 regulation on downstream gene expression, specifically miRNAs. Interestingly, ∆40p53 showed antagonistic regulation of miR-186-5p as compared to either p53 alone or a combination of both the isoforms. We have elucidated the miR-186-5p mediated effect of ∆40p53 in cell proliferation. Upon expression of ∆40p53, we observed a significant decrease in YY1 levels, an established target of miR-186-5p, which is involved in cell proliferation. Further assays with anti-miR-186 established the interdependence of ∆40p53− miR-186-5p−YY1− cell proliferation. The results unravel a new dimension toward the understanding of ∆40p53 functions, which seems to regulate cellular fate independent of p53FL.
| Item Type: | Journal Article |
|---|---|
| Publication: | Cell Cycle |
| Publisher: | Bellwether Publishing, Ltd. |
| Additional Information: | The copyright of this article belongs to the Authors. |
| Keywords: | cell proliferation; miR-186-5p; P53 isoform; YY1; ∆40p53 |
| Department/Centre: | Division of Biological Sciences > Microbiology & Cell Biology |
| Date Deposited: | 12 Mar 2021 15:57 |
| Last Modified: | 09 Jun 2023 09:10 |
| URI: | https://eprints.iisc.ac.in/id/eprint/68379 |
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