Attenuation methods for live vaccines

Hajra, D and Datey, A and Chakravortty, D (2020) Attenuation methods for live vaccines. [Book Chapter]

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Abstract

Vaccination was developed by Edward Jenner in 1796. Since then, vaccination and vaccine development research has been a hotspot of research in the scientific community. Various ways of vaccine development are successfully employed in mass production of vaccines. One of the most successful ways to generate vaccines is the method of virulence attenuation in pathogens. The attenuated strains of viruses, bacteria, and parasites are used as vaccines which elicit robust immune response and confers protection against virulent pathogens. This chapter brings together the most common and efficient ways of generating live attenuated vaccine strains in viruses, bacteria, and parasites. © Springer Science+Business Media, LLC, part of Springer Nature 2021.

Item Type:	Book Chapter
Publication:	Methods in Molecular Biology
Series.:	Methods in Molecular Biology
Publisher:	Humana Press Inc.
Additional Information:	Copyright for this Book belongs to Humana Press Inc.
Keywords:	Live attenuated strains, Gene inactivation, Mutagenesis, Irradiation, microRNA
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited:	19 Oct 2020 11:04
Last Modified:	19 Oct 2020 11:04
URI:	http://eprints.iisc.ac.in/id/eprint/66733

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