Rhodium(III)-Catalyzed C-H Activation: A Cascade Approach for the Regioselective Synthesis of Fused Heterocyclic Lactone Scaffolds

Kumar, AS and Prabhu, KR (2020) Rhodium(III)-Catalyzed C-H Activation: A Cascade Approach for the Regioselective Synthesis of Fused Heterocyclic Lactone Scaffolds. In: Journal of Organic Chemistry, 85 (5). pp. 3548-3559.

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Abstract

A Rh(III)-catalyzed cascade C-H activation; regioselective 4 + 2 oxidative annulation; and lactonization of aromatic acids, anhydrides, and acrylic acid derivatives with 4-hydroxy-2-Alkynoates have been disclosed. This strategy leads to fused heterocyclic lactone scaffolds in a single step with moderate functional group tolerance and excellent site selectivity. Besides, in one step, an antipode of the cephalosol intermediate natural product that contains a tricyclic isocoumarin framework has been synthesized. Copyright © 2020 American Chemical Society.

Item Type:	Journal Article
Publication:	Journal of Organic Chemistry
Publisher:	AMER CHEMICAL SOC
Additional Information:	The copyright of this article belongs to AMER CHEMICAL SOC
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	01 Jul 2020 09:45
Last Modified:	01 Jul 2020 09:45
URI:	http://eprints.iisc.ac.in/id/eprint/64954

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