Connecting CuA with metal centers of heme a, heme a(3), CuB and Zn by pathways with hydrogen bond as the bridging element in cytochrome c oxidase

Ramasarma, T and Vaigundan, D (2019) Connecting CuA with metal centers of heme a, heme a(3), CuB and Zn by pathways with hydrogen bond as the bridging element in cytochrome c oxidase. In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 510 (2). pp. 261-265.

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Abstract

Pathways formed of delocalized pi-electron systems and polar groups of polypeptide chains bridged by hydrogen bonds are referred as pi-H pathways. Suitable for electron transfer, these pathways in cytochrome c oxidase connect CuA, the source of electrons distributed in cytochrome c oxidase, with the metal centers, heme a, heme a(3), CuB, the constituents of the catalytic binuclear center. The unusually rapid electron transfer between heme a and heme a(3) would have been facilitated by the link pathway of a long sequence of alternate peptide unit and hydrogen bond spanning Pro336-Val374, referred as suprahelix, between these hemes. Two pathways between CuA center and zinc center, share some portions with purported proton-translocating channels, designated ``K'' and ``D''. (C) 2019 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Publication:	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Additional Information:	Copyright of this article belongs to ACADEMIC PRESS INC ELSEVIER SCIENCE
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	26 Mar 2019 06:41
Last Modified:	26 Mar 2019 06:41
URI:	http://eprints.iisc.ac.in/id/eprint/61922

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