Palladium catalyzed alkynylation of aryl halides (Sonogashira reaction) in water

Bhattacharya, Santanu and Sengupta, Saumitra (2004) Palladium catalyzed alkynylation of aryl halides (Sonogashira reaction) in water. In: Tetrahedron Letters, 45 (47). pp. 8733-8736.

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Abstract

The palladium catalyzed alkynylation of aryl halides (Sonogashira reaction) has been achieved in pure water without any additives or phase transfer catalysts. The reaction, which requires only 0.5mol% of $Pd(PPh_3)_4$ catalyst, is remarkably fast (30min at $70^oC$) producing high yields of the aryl alkyne products.

Item Type:	Journal Article
Publication:	Tetrahedron Letters
Publisher:	Elsevier
Additional Information:	The copyright of this article belongs to Elsevier.
Keywords:	Sonogashira reaction;Palladium;Water;Aryl halides;Alkynylation.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	31 Mar 2006
Last Modified:	19 Sep 2010 04:25
URI:	http://eprints.iisc.ac.in/id/eprint/6152

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