Jana, Avishek and Verma, Brijesh K and Garai, Aditya and Kondaiah, Paturu and Chakravarty, Akhil R (2018) Mitochondria localizing high-spin iron complexes of curcumin for photo-induced drug release. In: INORGANICA CHIMICA ACTA, 483 . pp. 571-578.
|
PDF
Inf_Chi_Act_483_571_2018.pdf - Published Version Download (987kB) | Preview |
|
|
PDF
corrigendum_ino_chi_act_493_127_2019.pdf - Published Version Download (522kB) | Preview |
Abstract
High-spin iron complexes Fe-II(L-1)(cur)]Cl (1), Fe-III(L-2)(cur)]Cl (2) and Fe-III(L-3)(cur)] (3), where L-1 is tris(2-pyridylmethyl)amine, HL2 is N,N-bis(2-pyridylmethyl)-N-(2-hydroxybenzyl)amine and H2L3 is N,N-dimethyl-N',N'-bis(4,6-ditertiarybutyl-2-hydroxybenzyl)ethylenediami ne and Hcur is curcumin, were synthesized, characterized and their redox-mediated and/or visible light induced release of curcumin, photo-induced DNA cleavage and anticancer activity studied. The molecular structures of 1-3 were optimized from DFT (density functional theory) calculations. The t(2g)(3)e(g)(2)-iron(III) complexes showed a curcumin based electronic spectral band at similar to 425 nm in 1:1 DMF/DPBS (Dulbecco's phosphate-buffered saline) and displayed the Fe(III)-Fe(II) redox couple near - 0.36 V vs. SCE (saturated calomel electrode) in DMF-0.1 M TBAP (tetrabutylammonium perchlorate). The complexes are avid binders to calf thymus DNA. Complex 1 showed photo-cleavage of pUC19 DNA in visible light of 446 nm forming center dot OH radicals as the reactive oxygen species. The complexes as curcumin carrier showed photo-cytotoxicity in different cell lines on visible light activation. Imaging study showed their subcellular mitochondrial localization.
| Item Type: | Journal Article |
|---|---|
| Publication: | INORGANICA CHIMICA ACTA |
| Publisher: | ELSEVIER SCIENCE SA |
| Additional Information: | The Copyright for this article belong to ELSEVIER SCIENCE SA |
| Keywords: | Bioinorganic chemistry; Iron; Curcumin; Mitochondrial localization; Drug photo-release; DNA cleavage |
| Department/Centre: | Division of Biological Sciences > Molecular Reproduction, Development & Genetics Division of Chemical Sciences > Inorganic & Physical Chemistry |
| Date Deposited: | 09 Oct 2018 15:44 |
| Last Modified: | 01 Jun 2022 10:11 |
| URI: | https://eprints.iisc.ac.in/id/eprint/60835 |
Actions (login required)
 |
View Item |
