Microfluidic microscopy-assisted label-free approach for cancer screening: automated microfluidic cytology for cancer screening

Jagannadh, Veerendra Kalyan and Gopakumar, G and Subrahmanyam, Gorthi R K Sai and Gorthi, Sai Siva (2017) Microfluidic microscopy-assisted label-free approach for cancer screening: automated microfluidic cytology for cancer screening. In: MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 55 (5). pp. 711-718.

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Abstract

Each year, about 7-8 million deaths occur due to cancer around the world. More than half of the cancer-related deaths occur in the less-developed parts of the world. Cancer mortality rate can be reduced with early detection and subsequent treatment of the disease. In this paper, we introduce a microfluidic microscopy-based cost-effective and label-free approach for identification of cancerous cells. We outline a diagnostic framework for the same and detail an instrumentation layout. We have employed classical computer vision techniques such as 2D principal component analysis-based cell type representation followed by support vector machine-based classification. Analogous to criminal face recognition systems implemented with help of surveillance cameras, a signature-based approach for cancerous cell identification using microfluidic microscopy surveillance is demonstrated. Such a platform would facilitate affordable mass screening camps in the developing countries and therefore help decrease cancer mortality rate.

Item Type:	Journal Article
Publication:	MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
Additional Information:	Copy right for this article belongs to the SPRINGER HEIDELBERG, TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
Department/Centre:	Division of Physical & Mathematical Sciences > Instrumentation Appiled Physics
Date Deposited:	17 Jun 2017 04:08
Last Modified:	17 Jun 2017 04:08
URI:	http://eprints.iisc.ac.in/id/eprint/57237

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