Novel rhodanines with anticancer activity: design, synthesis and CoMSIA study

Mandal, Subhankar P and Mithuna, Mithuna and Garg, Aakriti and Sahetya, Sanjana S and Nagendra, SR and Sripad, HS and Manjunath, Mendon Manisha and Sitaram, Sitaram and Soni, Mukesh and Baig, Nasir R and Kumar, Vasanth S and Kumar, Prashantha BR (2016) Novel rhodanines with anticancer activity: design, synthesis and CoMSIA study. In: RSC ADVANCES, 6 (63). pp. 58641-58653.

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Abstract

Three different series of some novel N-substituted rhodanines were designed for anticancer activity and prepared from the corresponding dithiocarbamates. The synthesized compounds were analyzed by IR, NMR and MASS to confirm their structures. All the titled compounds were found to be of Z configuration based on NMR spectral analysis. All the synthesized rhodanines were screened for in vitro anticancer activity against MCF-7 breast cancer cells at the concentration of 10 mu g. The compounds showed moderate to significant cytotoxicity. Amongst them, interestingly, compounds 10, 22 and 33 with cinnamoyl substitution at the 5th position of the thiazolidine ring system showed significant activity. Further, we subjected all these compounds to a CoMSIA study to study their 3D quantitative structure activity relationships (3D QSAR). The illustration about the design of novel rhodanines, synthesis, analysis, activity against MCF-7 cells and SAR via CoMSIA study are reported here.

Item Type:	Journal Article
Publication:	RSC ADVANCES
Publisher:	ROYAL SOC CHEMISTRY
Additional Information:	Copy right for this article belongs to the ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	24 Aug 2016 10:38
Last Modified:	24 Aug 2016 10:38
URI:	http://eprints.iisc.ac.in/id/eprint/54430

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