Madhu, Chilakapati and Prabhu, Girish and Pal, Rumpa and Row, Guru TN and Sureshbabu, Vommina V (2015) Synthesis of Optically Active 2-Amino-1,3,4-oxadiazoles and their Hybrid Peptides. In: JOURNAL OF HETEROCYCLIC CHEMISTRY, 52 (5). pp. 1438-1446.
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Synthesis of 2-amino-1,3,4-oxadiazole derivatives of N-Cbz(benzyloxycarbonyl)/Boc-protected amino/peptide acids under sonication is described. The conditions involved in the present protocol are simple, mild, and racemization free. The utility of 2-amino group in the substituted oxadiazoles for the incorporation of peptide and ureido bonds to obtain hybrid peptidomimetics is also delineated. The 2-amino-1,3,4-oxadiazole 3b was obtained as a single crystal, and its molecular structure has been confirmed through X-ray crystallographic study.
| Item Type: | Journal Article |
|---|---|
| Publication: | JOURNAL OF HETEROCYCLIC CHEMISTRY |
| Publisher: | WILEY-BLACKWELL |
| Additional Information: | Copy right for this article belongs to the WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA |
| Department/Centre: | Division of Chemical Sciences > Solid State & Structural Chemistry Unit |
| Date Deposited: | 30 Oct 2015 06:55 |
| Last Modified: | 30 Oct 2015 06:55 |
| URI: | http://eprints.iisc.ac.in/id/eprint/52649 |
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