Structure Elucidation and Characterization of Different Thyroxine Polymorphs

Mondal, Santanu and Mugesh, Govindasamy (2015) Structure Elucidation and Characterization of Different Thyroxine Polymorphs. In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54 (37). pp. 10833-10837.

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Abstract

Thyroid hormones regulate almost every process in the body, including body temperature, growth, and heart rate. They influence carbohydrate metabolism, protein synthesis and breakdown, and cardiovascular, renal, and brain function. Two new polymorphs of synthetic L-thyroxine (T4) are reported and the effect of polymorphism on the solubility of this important hormone is shown. Conformational changes were also discovered to have a remarkable effect on the strength of halogen bonding and the reactivity of the CI bonds, which could have a significant effect on the hormone activity.

Item Type:	Journal Article
Publication:	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Publisher:	WILEY-V C H VERLAG GMBH
Additional Information:	Copy right for this article belongs to the WILEY-V C H VERLAG GMBH, BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
Keywords:	halogen bonding; iodine; metabolism; polymorphism; thyroxine
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	01 Oct 2015 04:33
Last Modified:	01 Oct 2015 04:33
URI:	http://eprints.iisc.ac.in/id/eprint/52472

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