Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum

Haldipur, Parthiv and Sivaprakasam, Iswariya and Periasamy, Vinod and Govindan, Subashika and Mani, Shyamala (2015) Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum. In: BIOLOGY OPEN, 4 (7). pp. 865-872.

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Abstract

The plane of division of granule neuron progenitors (GNPs) was analysed with respect to the pial surface in P0 to P14 cerebellum and the results showed that there was a significant bias towards the plane of cell division being parallel to pial surface across this developmental window. In addition, the distribution of beta-Catenin in anaphase cells was analysed, which showed that there was a significant asymmetry in the distribution of beta-Catenin in dividing GNPs. Further, inhibition of Sonic Hedgehog (Shh) signalling had an effect on plane of cell division. Asymmetric distribution of beta-Catenin was shown to occur towards the source of a localized extracellular cue.

Item Type:	Journal Article
Publication:	BIOLOGY OPEN
Publisher:	COMPANY OF BIOLOGISTS LTD
Additional Information:	Copy right for this article belongs to the COMPANY OF BIOLOGISTS LTD, BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL, CAMBS, ENGLAND
Keywords:	Cerebellum; Cell division; beta-Catenin; Sonic hedgehog
Department/Centre:	Division of Biological Sciences > Centre for Neuroscience
Date Deposited:	11 Aug 2015 06:48
Last Modified:	11 Aug 2015 06:48
URI:	http://eprints.iisc.ac.in/id/eprint/52061

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