Enantiospecific Formal Total Synthesis of Iriomoteolide 3a

Kumar, Mothish S and Prasad, Kavirayani R (2014) Enantiospecific Formal Total Synthesis of Iriomoteolide 3a. In: CHEMISTRY-AN ASIAN JOURNAL, 9 (12). pp. 3431-3439.

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Abstract

A formal total synthesis of the marine macrolide iriomoteolide3a is described. Salient features of the synthesis include the elaboration of a -keto phosphonate derived from D-(-)-tartaric acid and the extension of a chiral butyrolactone derived from L-glutamic acid. Ring-closing metathesis is employed to construct the macrolactone core of the natural product.

Item Type:	Journal Article
Publication:	CHEMISTRY-AN ASIAN JOURNAL
Publisher:	WILEY-V C H VERLAG GMBH
Additional Information:	Copyright for this article belongs to the WILEY-V C H VERLAG GMBH, BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
Keywords:	iriomoteolide3a; lactones; macrocycles; natural products; total synthesis
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	12 Jan 2015 04:54
Last Modified:	12 Jan 2015 04:54
URI:	http://eprints.iisc.ac.in/id/eprint/50561

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