Synthon transferability probed with IR spectroscopy: cytosine salts as models for salts of lamivudine

Chakraborty, Shaunak and Ganguly, Somnath and Desiraju, Gautam R (2014) Synthon transferability probed with IR spectroscopy: cytosine salts as models for salts of lamivudine. In: CRYSTENGCOMM, 16 (22). pp. 4732-4741.

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Abstract

Co-crystal screening of the anti-HIV drug lamivudine was carried out with dicarboxylic acids as co-formers, and three of the resulting crystalline solids, two salts and a co-crystal, were studied with SCXRD, PXRD and FTIR spectroscopy. Salts of cytosine, a molecule that incorporates critical structural features of lamivudine, with the same co-formers, were taken as model systems for IR spectroscopic studies of the synthons in the salts of lamivudine. It is shown that different systems with the same synthon show very similar spectral signatures in the regions corresponding to the synthon absorptions. This reveals again the modular nature of the supramolecular synthon.

Item Type:	Journal Article
Publication:	CRYSTENGCOMM
Publisher:	ROYAL SOC CHEMISTRY
Additional Information:	copyright for this article belongs to ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	24 Jun 2014 07:45
Last Modified:	24 Jun 2014 07:45
URI:	http://eprints.iisc.ac.in/id/eprint/49331

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