IRES mediated translational regulation of p53 isoforms

Sharathchandra, Arandkar and Katoch, Aanchal and Das, Saumitra (2014) IRES mediated translational regulation of p53 isoforms. In: WILEY INTERDISCIPLINARY REVIEWS-RNA, 5 (1). pp. 131-139.

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Abstract

p53 is a well known tumor suppressor protein that plays a critical role in cell cycle arrest and apoptosis. It has several isoforms which are produced by transcriptional and posttranscriptional regulatory mechanisms. p53 mRNA has been demonstrated to be translated into two isoforms, full-length p53 (FL-p53) and a truncated isoform N-p53 by the use of alternative translation initiation sites. The mechanism of translation regulation of these two isoforms was further elucidated by the discovery of IRES elements in the p53 mRNA. These two IRESs were shown to regulate the translation of p53 and N-p53 in a distinct cell-cycle phase-dependent manner. This review focuses on the current understanding of the regulation of p53 IRES mediated translation and the role of cis and trans acting factors that influence expression of p53 isoforms. (C) 2013 John Wiley & Sons, Ltd.

Item Type:	Journal Article
Publication:	WILEY INTERDISCIPLINARY REVIEWS-RNA
Publisher:	WILEY-BLACKWELL
Additional Information:	copyright for this article belongs to WILEY-BLACKWELL,NJ USA
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	21 Jan 2014 08:50
Last Modified:	21 Jan 2014 08:50
URI:	http://eprints.iisc.ac.in/id/eprint/48204

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