Spark plasma sintered HA-Fe3O4-based multifunctional magnetic Bbiocomposites

Bajpai, Indu and Balani, Kantesh and Basu, Bikramjit (2013) Spark plasma sintered HA-Fe3O4-based multifunctional magnetic Bbiocomposites. In: Journal of the American Ceramic Society, 96 (7). pp. 2100-2108.

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Abstract

Although HA is highly biocompatible, one of the major disadvantages of HA include the lack of antibacterial property. In an earlier study, we demonstrated the potential role of magnetic field stimulation on bactericidal property in vitro. Following this, it was hypothesized that antibacterial property can be realized if bacteria are grown on magnetic biocomposites in vitro. In addressing this issue, this study demonstrates the development of HA-Fe3O4-based magnetic substrate with multifunctional properties. For this purpose, HA-xFe(3)O(4) (x: 10, 20 and 40wt%) powder compositions were sintered using uniquely designed spark plasma sintering conditions (three stage sintering with final holding temperature of 1050 degrees C for 5min). A saturation magnetization of 24emu/g is measured with HA-40%Fe3O4. Importantly, all the HA-Fe3O4 composites demonstrated bactericidal property by rupturing the membrane of Escherichia coli bacteria, while supporting cell growth of metabolically active human fetal osteoblast cells over 8d culture. A systematic decrease in bacterial viability with Fe3O4 addition is consistent with a commensurate increase in reactive oxygen species (ROS).

Item Type:	Journal Article
Publication:	Journal of the American Ceramic Society
Publisher:	Wiley-Blackwell
Additional Information:	Copyright of this article belongs to Wiley-Blackwell.
Department/Centre:	Division of Chemical Sciences > Materials Research Centre
Date Deposited:	02 Jan 2014 06:39
Last Modified:	02 Jan 2014 06:39
URI:	http://eprints.iisc.ac.in/id/eprint/48119

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