A catalytic michael/horner-wadsworth-emmons cascade reaction for enantioselective synthesis of thiochromenes

Choudhury, Abhijnan Ray and Mukherjee, Santanu (2013) A catalytic michael/horner-wadsworth-emmons cascade reaction for enantioselective synthesis of thiochromenes. In: Advanced Synthesis & Catalysis, 355 (10). pp. 1989-1995.

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Abstract

A catalytic enantioselective sulfa-Michael/Horner-Wadsworth-Emmons reaction cascade has been developed, taking advantage of phosphonate as an electrophilic activator and a traceless binding site. Using a chiral bifunctional urea derivative as the catalyst, a variety of aryl and heteroaryl substituted thiochromenes was obtained in excellent yield with a high level of enantioselectivity.

Item Type:	Journal Article
Publication:	Advanced Synthesis & Catalysis
Publisher:	John Wiley and Sons
Additional Information:	Copyright of this article belongs to John Wiley and Sons.
Keywords:	Asymmetric Catalysis; Bifunctional Catalysis; Cascade Reactions; Horner-Wadsworth-Emmons Reaction; Sulfa-Michael Addition; Thiochromenes
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	06 Jan 2014 10:05
Last Modified:	06 Jan 2014 10:05
URI:	http://eprints.iisc.ac.in/id/eprint/48118

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