Laser receptive polyelectrolyte thin films doped with biosynthesized silver nanoparticles for antibacterial coatings and drug delivery applications

Sripriya, Jaganathan and Anandhakumar, Sundaramurthy and Achiraman, Shanmugam and Antony, Jacob Joe and Siva, Durairaj and Raichur, Ashok M (2013) Laser receptive polyelectrolyte thin films doped with biosynthesized silver nanoparticles for antibacterial coatings and drug delivery applications. In: INTERNATIONAL JOURNAL OF PHARMACEUTICS, 457 (1). pp. 206-213.

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Abstract

We report a simple method to fabricate multifunctional polyelectrolyte thin films to load and deliver the therapeutic drugs. The multilayer thin films were assembled by the electrostatic adsorption of poly (allylamine hydrochloride) (PAH) and dextran sulfate (DS). The silver nanoparticles (Ag NPs) biosynthesized from novel Hybanthus enneaspermus leaf extract as the reducing agent were successfully incorporated into the film. The biosynthesized Ag NPs showed excellent antimicrobial activity against the range of enteropathogens, which could be significantly enhanced when used with commercial antibiotics. The assembled silver nano composite multilayer films showed rupture and deformation when they are exposed to laser. The Ag NPs act as an energy absorption center, locally heat up the film and rupture it under laser treatment. The antibacterial drug, moxifloxacin hydrochloride (MH) was successfully loaded into the multilayer films. The total amount of MH release observed was about 63% which increased to 85% when subjected to laser light exposure. Thus, the polyelectrolyte thin film reported in our study has significant potential in the field of remote activated drug delivery, antibacterial coatings and wound dressings. (C) 2013 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Publication:	INTERNATIONAL JOURNAL OF PHARMACEUTICS
Publisher:	ELSEVIER SCIENCE BV
Additional Information:	copyright for this article belongs to ELSEVIER SCIENCE,NETHERLANDS
Keywords:	Hybanthus enneaspermus; Polyelectrolyte thin films; Laser responsive; Drug carriers; Antimicrobicidal; Moxifloxacin hydrochloride
Department/Centre:	Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	19 Dec 2013 10:21
Last Modified:	19 Dec 2013 10:21
URI:	http://eprints.iisc.ac.in/id/eprint/47946

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