Synthetic glutathione peroxidase mimics: effect of nucleophilicity of the aryl thiol cofactor on the antioxidant activity

Bhabak, Krishna Pada and Bhowmick, Debasish and Mugesh, Govindasamy (2013) Synthetic glutathione peroxidase mimics: effect of nucleophilicity of the aryl thiol cofactor on the antioxidant activity. In: Indian Journal of Chemistry Sec A: Inorganic,Bio-inorganic, Physical Theoretical and Analytical Chemistry, 52 (8-9). pp. 1019-1025.

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Abstract

Catalytic activity of a series of potent amide- and amine-based organoselenium compounds are studied in the presence of various aromatic thiols having electron donating and electron withdrawing substituents on the phenyl ring. This study suggests that the antioxidant activities of the synthetic GPx mimics can be significantly increased by the incorporation of a suitable electron donating group on the phenyl ring of an aromatic thiol.

Item Type:	Journal Article
Publication:	Indian Journal of Chemistry Sec A: Inorganic,Bio-inorganic, Physical Theoretical and Analytical Chemistry
Publisher:	National Institute of Science Communication and Information Resources
Additional Information:	Copyright of this article belongs to National Institute of Science Communication and Information Resources.
Keywords:	Glutathione Peroxidase; Antioxidants; Organoselenium Compounds; Aromatic Thiols; Peroxide Reduction; Thiols; Enzymatic Activity; Enzyme Mimics
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	23 Sep 2013 08:40
Last Modified:	23 Sep 2013 08:40
URI:	http://eprints.iisc.ac.in/id/eprint/47405

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