Flux density calibration in diffuse optical tomographic systems

Biswas, Samir Kumar and Rajan, Kanhirodan and Vasu, Ram M (2013) Flux density calibration in diffuse optical tomographic systems. In: JOURNAL OF BIOMEDICAL OPTICS, 18 (2).

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Abstract

The solution of the forward equation that models the transport of light through a highly scattering tissue material in diffuse optical tomography (DOT) using the finite element method gives flux density (Phi) at the nodal points of the mesh. The experimentally measured flux (U-measured) on the boundary over a finite surface area in a DOT system has to be corrected to account for the system transfer functions (R) of various building blocks of the measurement system. We present two methods to compensate for the perturbations caused by R and estimate true flux density (Phi) from U-measured(cal). In the first approach, the measurement data with a homogeneous phantom (U-measured(homo)) is used to calibrate the measurement system. The second scheme estimates the homogeneous phantom measurement using only the measurement from a heterogeneous phantom, thereby eliminating the necessity of a homogeneous phantom. This is done by statistically averaging the data (U-measured(hetero)) and redistributing it to the corresponding detector positions. The experiments carried out on tissue mimicking phantom with single and multiple inhomogeneities, human hand, and a pork tissue phantom demonstrate the robustness of the approach. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE) DOI: 10.1117/1.JBO.18.2.026023]

Item Type:	Journal Article
Publication:	JOURNAL OF BIOMEDICAL OPTICS
Publisher:	SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
Additional Information:	Copyright for this article belongs to SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS,USA
Keywords:	flux density estimation;optical tomography;instrumentation
Department/Centre:	Division of Physical & Mathematical Sciences > Instrumentation Appiled Physics Division of Physical & Mathematical Sciences > Physics
Date Deposited:	18 Mar 2013 05:27
Last Modified:	18 Mar 2013 05:27
URI:	http://eprints.iisc.ac.in/id/eprint/46075

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