DNA Binding and Oxidative Cleavage Activity of Ternary (alpha-Lipoic Acid) Copper(II) Complex of Heterocyclic Base

Chetana, PR and Rao, Ramakrishna and Lahiri, Debojyoti (2013) DNA Binding and Oxidative Cleavage Activity of Ternary (alpha-Lipoic Acid) Copper(II) Complex of Heterocyclic Base. In: SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY, 43 (3). pp. 289-295.

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Abstract

Ternary copper(II) complex Cu(a-lipo)(phen)(Cl)](NO3) where a-lipo = a-lipoic acid, phen is N, N-donor heterocyclic base, 1,10-phenanthroline was synthesized, characterized, and its DNA binding and cleavage activity were studied. Binding interactions of the complex with calf thymus (CT) DNA has been investigated by emission, viscosity, and DNA melting studies. The complex shows efficient oxidative cleavage of SC-DNA in the presence of 3-mercaptopropionic acid involving hydroxyl radical species, and results of control experiments exhibit the inhibition of DNA cleavage in the presence of hydroxyl radical scavengers, viz. DMSO and KI.

Item Type:	Journal Article
Publication:	SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY
Publisher:	TAYLOR & FRANCIS INC
Additional Information:	Copyright for this article belongs to TAYLOR & FRANCIS INC, PHILADELPHIA, USA
Keywords:	a-lipoic acid;copper;DNA binding;DNA cleavage;phenanthroline base
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	07 Mar 2013 11:41
Last Modified:	07 Mar 2013 11:41
URI:	http://eprints.iisc.ac.in/id/eprint/45939

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