Deiodination of Thyroid Hormones by Iodothyronine Deiodinase Mimics: Does an Increase in the Reactivity Alter the Regioselectivity?

Manna, Debasish and Mugesh, Gowndasamy (2011) Deiodination of Thyroid Hormones by Iodothyronine Deiodinase Mimics: Does an Increase in the Reactivity Alter the Regioselectivity? In: Journal of the American Chemical Society, 133 (26). pp. 9980-9983.

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Abstract

Organoselenium compounds as functional mimics of iodothyronine deiodinase are described. The naphthyl-based compounds having two selenol groups are remarkably efficient in the inner-ring deiodination of thyroxine. The introduction of a basic amino group in close proximity to one of the selenol moieties enhances the deiodination. This study suggests that an increase in the nucleophilic reactivity of the conserved Cys residue at the active site of deiodinases is very important for effective deiodination.

Item Type:	Journal Article
Publication:	Journal of the American Chemical Society
Publisher:	American Chemical society
Additional Information:	Copyright of this article belongs to American Chemical society.
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	29 Jul 2011 10:51
Last Modified:	29 Jul 2011 10:51
URI:	http://eprints.iisc.ac.in/id/eprint/39604

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