Vempati, UD and Kondaiah, P (1998) Molecular organization of the gene encoding Xenopus laevis transforming growth factor-beta 5. In: Biochemistry & Molecular Biology International, 45 (5). pp. 997-1003.
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Transforming growth factor-beta s (TGF-beta 5) are multifunctional polypeptides, known to influence proliferation and differentiation of many cell types. TGF-beta 5 cDNA was cloned from Xenopus laevis and this isoform is unique to the amphibians. Here, we report the isolation and characterization of the TGF-beta 5 genomic clones to determine the structure of TGF-beta 5 gene. The gene consists of seven exons and all intron-exon boundaries follow the GT-AG consensus. The organization of TGF-beta 5 gene was identical to that of the mammalian TGF-beta isoforms, with the exception of position of the first splice junction. We determined the size of TGF-beta 5 gene to be approximately 20 kb.
| Item Type: | Journal Article |
|---|---|
| Publication: | Biochemistry & Molecular Biology International |
| Publisher: | Academic Press Aust |
| Additional Information: | Copyright of this article belongs to Academic Press Aust. |
| Keywords: | transforming growth factor-beta;intron;exon;gene structure; genomic library;Xenopus laevis. |
| Department/Centre: | Division of Biological Sciences > Molecular Reproduction, Development & Genetics |
| Date Deposited: | 09 Jun 2011 06:28 |
| Last Modified: | 09 Jun 2011 06:28 |
| URI: | http://eprints.iisc.ac.in/id/eprint/38172 |
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