Madyastha, KM and Raj, Paul C (1993) Studies on the metabolism of a monoterpene ketone, R-(+)-pulegone-a hepatotoxin in rat: isolation and characterization of new metabolites. In: Xenobiotica, 23 (5). pp. 509-518.
Full text not available from this repository. (Request a copy)Abstract
1. The metabolic disposition of R-(+)-pulegone (1) was examined in rats following four daily oral doses (250 mg/kg). 2. Six metabolites, namely pulegol (II), 2-hydroxy-2-(1-hydroxy-1-methylethyl)-5-methylcyclohexanone (III), 3,6-dimethyl-7a-hydroxy-5,6,7,7a-tetrahydro-2(4H)-benzofuranone (IV), menthofuran (V), 5-methyl-2-(1-methyl-1-carboxyethylidene)cyclohexanone (VI), and 5-methyl-5-hydroxy-2-(1-hydroxy-1-carboxyethyl)cyclohexanone (VII) have previously been isolated from rat urine, and identified (Moorthy et al. (1989a). Eight new metabolites have now been isolated from rat urine, namely, 5-hydroxy-pulegone (VIII), piperitone (IX), piperitenone (X), 7-hydroxy-piperitone (XI), 8-hydroxy piperitone (XII), p-cresol (XIII), geranic acid (XIV) and neronic acid (XV). These were identified by n.m.r., i.r. and mass spectrometry. 3. Based on these results, metabolic pathways for the biotransformation of R-(+)-pulegone in rat have been proposed.
| Item Type: | Journal Article |
|---|---|
| Publication: | Xenobiotica |
| Publisher: | Informa plc |
| Additional Information: | Copyright of this article belongs to Informa plc. |
| Department/Centre: | Division of Chemical Sciences > Organic Chemistry |
| Date Deposited: | 11 Mar 2011 07:12 |
| Last Modified: | 11 Mar 2011 07:12 |
| URI: | http://eprints.iisc.ac.in/id/eprint/35843 |
Actions (login required)
 |
View Item |
