Bhat, Gunaje Jayarama and Padmanaban, Govindarajan (1988) Heme is a positive regulator of cytochrome P-450 gene transcription. In: Archives of Biochemistry and Biophysics, 264 (2). pp. 584-590.
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Abstract
Inhibitors of heme biosynthesis such as CoCl2, 3-amino-1,2,4-triazole, and thioacetamide block the 3-methylcholanthrene-mediated induction of cytochrome P-450 (c + d) messenger RNAs and their transcription in rat liver. This effect is specific, since the messenger RNA levels for albumin and glutathione transferase (Ya + Yc) and their transcription are not significantly influenced under conditions of heme depletion. Exogenous administration of heme at very low doses (50 μg/100 g body wt) is able to completely counteract the effects of the heme biosynthetic inhibitors on cytochrome P-450 (c + d) messenger RNA levels and their transcription. This constitutes a direct proof for the role of heme as a positive regulator of cytochrome P-450 gene transcription.
Item Type: | Journal Article |
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Publication: | Archives of Biochemistry and Biophysics |
Publisher: | Elsevier science |
Additional Information: | Copyright of this article belongs to Elsevier science. |
Department/Centre: | Division of Biological Sciences > Biochemistry |
Date Deposited: | 20 Sep 2010 04:25 |
Last Modified: | 20 Sep 2010 04:25 |
URI: | http://eprints.iisc.ac.in/id/eprint/32233 |
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