Encapsulation and release of rifampicin using poly(vinyl pyrrolidone)-poly (methacrylic acid) polyelectrolyte capsules

Kumar, Anil KN and Ray, Basu S and Nagaraja, Valakunja and Raichur, Ashok M (2009) Encapsulation and release of rifampicin using poly(vinyl pyrrolidone)-poly (methacrylic acid) polyelectrolyte capsules. In: Materials Science and Engineering: C, 29 (8). pp. 2508-2513.

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Abstract

Poly(vinyl pyrrolidone) and poly(methacrylic acid) multilayer capsules based on hydrogen bonding have been prepared by the layer-by-layer approach and used to encapsulate and release rifampicin, an antituberculosis drug. Removal of silica core using a buffer of ammonium fluoride and hydrofluoric acid at about pH 3 was found to produce better capsules than hydrofluoric acid alone. An eight-layered capsule had a wall thickness of 20 rim. Maximum encapsulation was found to be about 86 mu g at 40 degrees C with 1 +/- 0.2 x 10(6) capsules. Release studies showed a burst kind of release and maximum release was obtained above pH 7 where the capsules disintegrate rapidly thereby releasing the drug in a short period. Interactions studies with Mycobacterium smegmatis showed that the capsules were cytocompatible and the released drug functioned with the same efficacy as the free drug.

Item Type:	Journal Article
Publication:	Materials Science and Engineering: C
Publisher:	Elsevier Science
Additional Information:	Copyright for this article belongs to Elsevier Science.
Keywords:	Polyelectrolyte; Multilayer; Drug delivery; Rifampicin; Encapsulation; Release
Department/Centre:	Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy) Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	07 Dec 2009 05:39
Last Modified:	19 Sep 2010 05:52
URI:	http://eprints.iisc.ac.in/id/eprint/24974

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