Classification of Nonenzymatic Homologues of Protein Kinases

Anamika, K and Abhinandan, KR and Deshmukh, K and Srinivasan, N (2009) Classification of Nonenzymatic Homologues of Protein Kinases. In: Comparative and Functional Genomics, 2009 . pp. 1-7.

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Abstract

Protein Kinase-Like Non-kinases (PKLNKs), which are closely related to protein kinases, lack the crucial catalytic aspartate in the catalytic loop, and hence cannot function as protein kinase, have been analysed. Using various sensitive sequence analysis methods, we have recognized 82 PKLNKs from four higher eukaryotic organisms, namely, Homo sapiens, Mus musculus, Rattus norvegicus, and Drosophila melanogaster. On the basis of their domain combination and function, PKLNKs have been classified mainly into four categories: (1) Ligand binding PKLNKs, (2) PKLNKs with extracellular protein-protein interaction domain, (3) PKLNKs involved in dimerization, and (4) PKLNKs with cytoplasmic protein-protein interaction module. While members of the first two classes of PKLNKs have transmembrane domain tethered to the PKLNK domain, members of the other two classes of PKLNKs are cytoplasmic in nature. The current classification scheme hopes to provide a convenient framework to classify the PKLNKs from other eukaryotes which would be helpful in deciphering their roles in cellular processes.

Item Type:	Journal Article
Publication:	Comparative and Functional Genomics
Publisher:	HINDAWI PUBLISHING CORPORATION
Additional Information:	Copyright of this article belongs to K. Anamika et al., 2009
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	23 Oct 2009 11:17
Last Modified:	19 Sep 2010 05:50
URI:	http://eprints.iisc.ac.in/id/eprint/24549

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