Complexity analysis of EEG in patients with schizophrenia using fractal dimension

Raghavendra, BS and Dutt, D Narayana and Halahalli, Harsha N and John, John P (2009) Complexity analysis of EEG in patients with schizophrenia using fractal dimension. In: Physiological Measurement, 30 (8). pp. 795-808.

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Abstract

We computed Higuchi's fractal dimension (FD) of resting, eyes closed EEG recorded from 30 scalp locations in 18 male neuroleptic-naive, recent-onset schizophrenia (NRS) subjects and 15 male healthy control (HC) subjects, who were group-matched for age. Schizophrenia patients showed a diffuse reduction of FD except in the bilateral temporal and occipital regions, with the reduction being most prominent bifrontally. The positive symptom (PS) schizophrenia subjects showed FD values similar to or even higher than HC in the bilateral temporo-occipital regions, along with a co-existent bifrontal FD reduction as noted in the overall sample of NRS. In contrast, this increase in FD values in the bilateral temporo-occipital region was absent in the negative symptom (NS) subgroup. The regional differences in complexity suggested by these findings may reflect the aberrant brain dynamics underlying the pathophysiology of schizophrenia and its symptom dimensions. Higuchi's method of measuring FD directly in the time domain provides an alternative for the more computationally intensive nonlinear methods of estimating EEG complexity.

Item Type:	Journal Article
Publication:	Physiological Measurement
Publisher:	Institute of Physics
Additional Information:	Copyright of this article belongs to Institute of Physics.
Keywords:	schizophrenia;electroencephalogram;Fractal Dimension; Complexity;Symptom Dimensions.
Department/Centre:	Division of Electrical Sciences > Electrical Communication Engineering
Date Deposited:	18 Aug 2009 05:03
Last Modified:	19 Sep 2010 05:41
URI:	http://eprints.iisc.ac.in/id/eprint/22256

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