Characterization of a toxin from Parthenium hysterophorus and its mode of excretion in animals

Narasimhan, TR and Murthy, Keshava BS and Harindranath, N and Rao, Subba PV (1984) Characterization of a toxin from Parthenium hysterophorus and its mode of excretion in animals. In: Journal of Biosciences, 6 (5). pp. 729-738.

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Abstract

Fractionation of methanolic extracts of air dried aerial parts ofParthenium resulted in the isolation of a toxic constituent which was identified as parthenin, the major sesquiterpene lactone from the weed. The LD50 (minimal lethal dose required to cause 50% mortality) for parthenin in rats was 42 mg/kg body weight. When [3H]-parthenin was given orally or by intravenous administration, radioactivity appeared in the milk of lactating laboratory and dairy animals. Tissue distribution of radioactivity revealed that maximum label was detectable in kidneys.

Item Type:	Journal Article
Publication:	Journal of Biosciences
Publisher:	Springer
Additional Information:	Copyright of this article belongs Indian Academy of Sciences
Keywords:	Compositae;parthenin;sesquiterpene lactone;LD50;toxicity; organelle drug distribution.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	10 Aug 2009 04:59
Last Modified:	19 Sep 2010 05:40
URI:	http://eprints.iisc.ac.in/id/eprint/22148

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