Influence of clofibrate administration on the rate of synthesis of macromolecules in regenerating rat liver

Mittal, Balraj and Kurup, CK Ramakrishna (1980) Influence of clofibrate administration on the rate of synthesis of macromolecules in regenerating rat liver. In: Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 609 (3). pp. 475-482. (In Press)

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Abstract

Administration of the antihypercholesterolaemic drug clofibrate stimulates the rates of synthesis of nucleic acids and proteins in rat liver. The biosynthesis of mitochondrial proteins also is enhanced by the drug. In drug-fed animals, the rates of incorporation in vivo of radioactive precursors into DNA, RNA and proteins are stimulated even when the liver undergoes regeneration following partial hepatectomy. The rate of synthesis of mitochondrial proteins in the regenerative phase is higher in clofibrate-fed animals. These effects are consistent with the hepatomegalic and mitochondria-proliferating property of the drug.

Item Type:	Journal Article
Publication:	Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	Nucleic acid synthesis; Mitochondrial protein synthesis; Clofibrate; Regeneration; (Rat liver).
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	21 Aug 2009 10:35
Last Modified:	19 Sep 2010 05:32
URI:	http://eprints.iisc.ac.in/id/eprint/20350

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