Immunogenic and protective properties of haemagglutinin protein (H) of Rinderpest virus expressed by a recombinant baculovirus

Naik, Sangeeta and Renukaradhya, GJ and Rajasekhar, M and Shaila, MS (1997) Immunogenic and protective properties of haemagglutinin protein (H) of Rinderpest virus expressed by a recombinant baculovirus. In: Vaccine, 15 (6-7). pp. 603-607.

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Abstract

The hemagglutinin (H) protein of Rinderpest virus expressed by a recombinant buculovirus used as a vaccine produced high titres of neutralizing antibody to Rinderpest virus in the vaccinated cattle, comparable to the levels produced by live attenuated vaccine. The immunized cattle were protected against a vaccine-virus challenge, as demonstrated by the failure of development of antibodies to N protein of the vaccine virus. The lack of replication of vaccine virus in the immunized cattle indicated that they are capable of showing a protective response if challenged with a virulent virus.

Item Type:	Journal Article
Publication:	Vaccine
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	Haemagglutinin;Rinderpest virus;recombinant baculovirus;protective immunity.
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	17 Aug 2009 06:03
Last Modified:	19 Sep 2010 05:28
URI:	http://eprints.iisc.ac.in/id/eprint/19529

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