A semi-empirical SCF-MO study on the base-pairing properties of 8-oxopurines: Significance for mutagenicity

Venkateswarlu, D and Lyngdoh, RHD and Bansal, M (1997) A semi-empirical SCF-MO study on the base-pairing properties of 8-oxopurines: Significance for mutagenicity. In: Journal Of The Chemical Society-Perkin Transactions 2 (3). pp. 621-626.

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Abstract

C-8-Oxidised purines like 7-hydro-8-oxoguanine (8OG)and 7-hydro-8-oxoadenine (8OA) are known as products of oxidative DNA damage. Semiempirical molecular orbital calculations at the PM3 SCF-MO level are used to investigate the base-pairing properties of these bases in an attempt to understand their mutagenic properties. A detailed analysis of the base-pairing properties of these bases leads to an identification of the most probable pairing schemes involved in mutagenic base-mispairing. It is suggested that both bases are capable of inducing transversional as well as transitional mutations via base-mispairing. The results presented are largely in consonance with available experimental reports.

Item Type:	Journal Article
Publication:	Journal Of The Chemical Society-Perkin Transactions 2
Publisher:	Royal Society of Chemistry
Additional Information:	Copyright of this article belongs to Royal Society of Chemistry.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	10 Feb 2010 07:04
Last Modified:	19 Sep 2010 05:01
URI:	http://eprints.iisc.ac.in/id/eprint/18408

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