Controlled synthesis of plate-shaped hydroxyapatite and implications for the morphology of the apatite phase in bone

Viswanath, B and Ravishankar, N (2008) Controlled synthesis of plate-shaped hydroxyapatite and implications for the morphology of the apatite phase in bone. In: Biomaterials, 29 (36). pp. 4855-4863.

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Abstract

A general methodology for predicting the conditions for the formation of plate-shaped structures by precipitation has been developed. The method has been applied for understanding the morphology of hydroxyapatite formed under different synthetic conditions. Morphology diagram has been developed in the form of pH–T diagrams to predict regions where plate-shaped hydroxyapatite is expected to form. The validity of the morphology diagram has been tested by critical experiments carried out at different conditions coupled with detailed microstructural analysis. Different morphologies ranging from single crystalline sheets, rods to equiaxed particles of hydroxyapatite are achieved by tuning the driving force of the precipitation reactions by varying the parameters such as pH and temperature in the absence of capping/surfactant agents. The synthesis and analysis presented here have important implications for understanding the plate-shaped morphology of apatite crystals that exist in the bone.

Item Type:	Journal Article
Publication:	Biomaterials
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	Hydroxyapatite; Growth factors; Microstructure; Interface; Crystal growth.
Department/Centre:	Division of Chemical Sciences > Materials Research Centre
Date Deposited:	09 Jul 2009 07:58
Last Modified:	19 Sep 2010 04:57
URI:	http://eprints.iisc.ac.in/id/eprint/17577

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