An enantiospecific approach to thapsanes from R-carvone: synthesis of (-)-thaps-8-en-5-oly

Srikrishna, A and Anebouselvy, K and Jagadeeshwar Reddy, T (2000) An enantiospecific approach to thapsanes from R-carvone: synthesis of (-)-thaps-8-en-5-oly. In: Tetrahedron Letters, 41 (34). pp. 6643-6647.

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Abstract

The first enantiospecific synthesis of a thapsane, containing three contiguous quaternary carbon atoms, is accomplished starting from R-carvone. An intramolecular alkylation and an intramolecular diazoketone cyclopropanation reaction were employed for the stereo- and regiospeci®c generation of three contiguous quaternary carbon atoms present in the thapsane framework.

Item Type:	Journal Article
Publication:	Tetrahedron Letters
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	R-carvone;intramolecular alkylation;carbon atoms.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	03 Jun 2009 06:10
Last Modified:	19 Sep 2010 04:52
URI:	http://eprints.iisc.ac.in/id/eprint/16563

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