Sivaramakrishnan, S and Ramasarma, T (1983) Noradrenaline stimulates succinate dehydrogenase through \beta -adrenergic receptors. In: Indian Journal of Biochemistry & Biophysics, 20 (1). pp. 16-22.
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Administration of noradrenaline (I) [51-41-2] to rats increased activities of succinate dehydrogenase (EC 1.3.99.1) [9002-02-2], succinate-neotetrazolium reductase [37217-40-6], and succinate oxidase [9014-35-1] in mitochondria obtained from liver, but not kidney and heart. The max. stimulation was obtained 2 h after treatment with the hormone. The stimulation required a crit., narrow range of I concn. The action of I was sensitive to propranolol, a \beta-adrenergic blocking agent. Treatment with theophylline and glucagon, known to increase intracellular concn. of cyclic AMP [60-92-4], and with 3,4-dihydroxyphenyl serine, known to be decarboxylated to I in cytosol, also showed a similar stimulation of succinate dehydrogenase. These studies provide an interesting example of stimulation of an enzyme on treatment of animals with I by a combined \beta-receptor and possible cytosolic levels of action of the hormone.
| Item Type: | Journal Article |
|---|---|
| Publication: | Indian Journal of Biochemistry & Biophysics |
| Publisher: | National Institute of Science Communication and Information Resources |
| Additional Information: | Copyright of this article belongs to National Institute of Science Communication and Information Resources |
| Department/Centre: | Division of Biological Sciences > Biochemistry |
| Date Deposited: | 15 Apr 2008 |
| Last Modified: | 27 Aug 2008 13:19 |
| URI: | http://eprints.iisc.ac.in/id/eprint/13677 |
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