Antigenic relationship between reactivity to hepatitis B e antigen and 19 kDa protein of Mycobacterium tuberculosis among the Tibetan settlers in Karnataka

Apte, Madhuri and Shamala, N and Ramakrishnan, T (1992) Antigenic relationship between reactivity to hepatitis B e antigen and 19 kDa protein of Mycobacterium tuberculosis among the Tibetan settlers in Karnataka. In: Journal of Biosciences, 17 (3). pp. 305-312.

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Abstract

McGlynn and her co-workers have reported that among the Vietnamese refugees in Philadelphia and among Alaskan natives who are hepatitis B carriers, there is a statistically significant association between a negative tuberculin test and the presence of hepatitis B e antigen. A repetition of this work among the population of Bangalore did not yield any significant results because of the very low incidence of hepatitis found among this population. However, on the basis of available data that hepatitis B infection is more prevalent among the Mongolian population than among people of other populations, the work was repeated among Tibetans who had settled down in Karnataka. This set of experiments showed that, contrary to the report of McGlynn et al, there is a statistically significant association between a positive tuberculin test and the presence of hepatitis B e antigen and that those individuals who showed the presence of hepatitis B e antigen exhibited less severe form of the disease than those who were negative to this antigen. These findings suggested that immunity to tuberculosis and hepatitis B infections may have a common underlying principle. Data bank search revealed a stretch of amino acid sequences which is common to hepatitis B e antigen and 19 kDa antigen of Mycobacterium tuberculosis. The significance of these results is discussed.

Item Type:	Journal Article
Publication:	Journal of Biosciences
Publisher:	Indian Academy of Sciences
Additional Information:	Copyright of this article belongs to Indian Academy of Sciences
Keywords:	Mycobacterium tuberculosis;hepatitis B;M. tuberculosis 19 kDa antigen;hepatitis B e antigen;tuberculin test;nucleotide sequences;amino acid sequences;epidemiology of hepatitis B
Department/Centre:	Division of Physical & Mathematical Sciences > Physics Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	23 Feb 2008
Last Modified:	21 Dec 2010 10:31
URI:	http://eprints.iisc.ac.in/id/eprint/12884

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