Prasad, Kavirayani R and Chandrakumar, Appayee (2007) Stereoselective syntheses of \gamma-alkyl (aryl)-$\alpha$, $_\beta$ -dihydroxy-\gamma-butyrolactones and naturally occurring lipid guggultetrol. In: Tetrahedron, 63 (8). pp. 1798-1805.
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Abstract
\gamma-Oxo-butyramides derived from tartaric acid serve as excellent precursors for the synthesis of \gamma-alkyl (aryl)-$\alpha$, $_\beta$-dihydroxy-\gamma- butyrolactones and for the synthesis of tetrols containing three contiguous stereogenic centres. The methodology presented here is general for the synthesis of \gamma-alkyl (aryl)-$\alpha$, $_\beta$-dihydroxy-\gamma-butyrolactones.Utility of the chiral building block was demonstrated by the synthesis of naturally occurring lipid guggultetrol.
Item Type: | Journal Article |
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Publication: | Tetrahedron |
Publisher: | Elsevier |
Additional Information: | Copyright of this article belongs to Elsevier. |
Keywords: | g-Butyrolactone;Stereoselective reduction;L-(+)-Tartaric acid;Guggultetrol |
Department/Centre: | Division of Chemical Sciences > Organic Chemistry |
Date Deposited: | 27 Mar 2007 |
Last Modified: | 19 Sep 2010 04:36 |
URI: | http://eprints.iisc.ac.in/id/eprint/10240 |
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